Organic acid Totally Explained

Everything about Organic Acid totally explained

An organic acid is an organic compound with acidic properties. The most common organic acids are the carboxylic acids whose acidity is associated with their carboxyl group -COOH. Sulfonic acids, containing the group OSO₃H, are relatively stronger acids. The relative stability of the conjugate base of the acid determines its acidity. Other groups can also confer acidity, usually weakly: -OH, -SH, enol group, and the phenol group. In biological systems organic compounds containing only these groups are not generally referred to as organic acids.
A few common examples include:

Characteristics

Generally, organic acids are weak acids and don't dissociate completely in water, whereas the strong mineral acids do. Lower molecular weight organic acids such as formic and acetic acids are miscible in water, but higher molecular weight organic acids such as benzoic acid are insoluble in molecular (neutral) form.
On the other hand, most organic acids are very soluble in organic solvents. p-toluenesulfonic acid is a comparatively strong acid used in organic chemistry often because it's able to dissolve in the organic reaction solvent.
Exceptions to these solubility characteristics exist in the presence of other substituents which affect the polarity of the compound.

Applications

Simple organic acids like formic or acetic acids are used for oil and gas well stimulation treatments. These organic acids are much less reactive with metals than are strong mineral acids like HCl or mixtures of HCl and HF. For this reason, organic acids are used at high temperatures or when long contact times between acid and pipe are needed.
The conjugate bases of organic acids such as citrate and acetate are often used in biologically-compatible buffer solutions.
Citric and oxalic acids are used as rust removal. As acids, they can dissolve the iron oxides, but without damaging the base metal like stronger mineral acids. In the dissociated form, they may be able to chelate the metal ions, helping to speed removal.
Biological systems create many and more complex organic acids such as L-lactic, citric and D-glucuronic acids that contain hydroxyl or carboxyl groups. Human blood and urine contain these plus organic acid degradation products of amino acids, neurotransmitters and intestinal bacterial action on food components. Examples of these categories are alpha-ketoisocaproic, vanilmandelic and D-lactic acids, derived from catabolism of L-leucine and epinephrine (adrenaline) by human tissues and catabolism of dietary carbohydrate by intestinal bacteria, respectively.

Application in nutrition and animal feeds

Research in the food preservation field has brought clear explanation on the mode of action of organic acids on bacteria and numerous trials have shown that the concept works in animal nutrition.
   Organic acids have been used successfully in pig production for more than 25 years and continue to be the alternative of choice. Even if less work has been done in poultry, the Organic Acids are very efficacious and their use is adapted to the physiology and anatomy of poultry.
   Organic acids (C1-C7) are widely distributed in nature as normal constituents of plants or animal tissues. They are also formed through microbial fermentation of carbohydrates mainly in the large intestine. They are sometimes found in their sodium, potassium or calcium form.
   The key basic principle on the mode of action of organic acids on bacteria is that non-dissociated (non-ionized) organic acids can penetrate the bacteria cell wall and disrupt the normal physiology of certain types of bacteria that we call “pH-sensitive” meaning that they can't tolerate a wide internal and external pH gradient. Among those bacteria are E.coli, Salmonella spp., C. perfringens, Listeria monocytogenes, Campylobacter spp.
   Upon passive diffusion of organic acids into the bacteria, where the pH is near of above neutrality, the acids will dissociate and lower the bacteria internal pH, leading to situations that will impair or stop the growth of bacteria. On the other hand, the anionic part of the organic acids that can't escape the bacteria in its dissociated form will accumulate within the bacteria and disrupt many metabolic functions and lead to osmotic pressure increase, incompatible with the survival of the bacteria.
   It has been well demonstrated that the state of the organic acids (undissociated or dissociated) is extremely important to define their capacity to inhibit the growth of bacteria, compared to undissociated acids.
   Logically, organic acids added to feeds should be protected to avoid their dissociation in the crop and in the intestine (high pH segments) and reach far into the GIT, where the bulk of the bacteria population is located.
   From the use of organic acids in poultry and pigs one can expect an improvement in performance similar or better than the antibiotic growth promoters, without the public health concern, a preventive effect on the intestinal problems like necrotic enteritis in chickens and Escherichia coli infection in young pigs. Also one can expect a reduction of the carrier state for Salmonella spp. & Campilobacter spp. Kansas State University recommends Kemgest, Syneracid, Digest acid, or Tetracid 500 as acidifiers to be fed to pigs weighing less than 12 lb as a complete diet.

Sources

Dibner J.J., P. Butin. 2002 - Use of organic acids as a model to study the impact of gut microflora on nutrition and metabolism. J. Appl. Poultry Res. 11:453-463

Patanen K.H., Z. Mroz. 1999 – Organic acids for preservation. Disinfection, sterilization & preservation (S.S. Block editor) Lea Febiger, Philadelphia PA.

Brul S., P. Coote. 1999 – Preservative agents in foods, mode of action and microbial resistance mechnismes. Intl. J. Food Microbiology 50:1-17Further Information

Get more info on 'Organic Acid'.

External Link Exchanges

Do you know how hard it is to get a link from a large encyclopaedia? Well we're different and will prove it. To get a link from us just add the following HTML to your site on a relevant page:

<a href="http://organic_acid.totallyexplained.com">Organic acid Totally Explained</a>

Then simply click through this link from your web page. Our crawlers will verify your link, extract the title of your web page and instantly add a link back to it. If you like you can remove the words Totally Explained and embed the link in article text.
As long as your link remains in place, we'll keep our link to you right here. Please play fair - our crawlers are watching. Your site must be closely related to this one's topic. Any kind of spamming, dubious practises or removing the link will result in your link from us being dropped and, potentially, your whole site being banned.